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Gender dimorphism in clinical manifestation of sepsis, hemorrhage, and trauma is still under investigation. Several experimental studies have indicated a protective effect of estrogen. Nonetheless, the effect of gender on hepatic ischemia/reperfusion remains controversially discussed, and the influence of estrogen is still unclear. In the present study we investigated whether (i) hepatic ischemia/reperfusion...
The endothelial receptors that control leukocyte transmigration in the postischemic liver are not identified. Here, we tested the hypothesis that junctional adhesion molecule-A (JAM-A) is involved in leukocyte transmigration during hepatic ischemia-reperfusion (I/R). In wild-type, JAM-A-/-, and endothelial JAM-A-/- mice, leukocyte rolling and adhesion were quantified in venules and sinusoids using...
T cells are suggested to be involved in the induction of antigen-independent hepatic ischemia-reper-fusion (I/R) injury. In the present study, we analyzed the recruitment of T cell subpopulations in the postischemic liver in vivo and investigated by which pathway T cells mediate tissue injury. In a murine model of warm hepatic I/R (I: 90min, R: 30, 120 min), the recruitment of freshly isolated (magnetic...
Until now little is known about the potential of 3-nitroproprionic acid (3-NPA) to reduce ischemia/ reperfusion injury (IRI) of the rat liver in vivo. Male Brown-Norway rats were subjected to a model of segmental hepatic ischemia. To assess animal survival the non ischemic lobes at the time of reperfusion were resected. 3 groups were compared: sham-operated animals, non-treated animals and...
As the number of patients on the waiting list for organ transplantation is increasing, the expansion of the donor spectrum is of utmost importance. Steatosis is a common finding and in most cases the reason for organ refusal or dysfunction after transplantation. Because apoptotic cell death plays a pivotal role in the pathogenesis of the preservation-reperfusion injury of the liver, the aim of our...
Background: Primary graft dysfunction due to ischemia and reperfusion injury still represents a major problem in clinical liver transplantation. Cell stress induced by ischemia and reperfusion injury may induce apoptosis, which can be suppressed by bcl-2 in various cell types. The purpose of the study was to investigate the effect of adenoviral bcl-2 gene transfer on early graft function,...
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